Nutrients and Benefits
Our exclusive daily functional food powder is a powerhouse of bioavailable plant protein, fiber, vitamins, minerals, polyphenols, beta glucan, essential fatty acids, and antioxidants.
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Nutrients In Zivolife And Health Benefits
Beta Glucans boost immune function by activating immune cells (e.g., macrophages), supports gut health, and may reduce inflammation.
Clinical Study: A 2011 randomized controlled trial (RCT) published in Nutrition Journal tested beta-glucans from oats (Talalay et al., 2011).
Results: 60 participants with elevated cholesterol consumed 3g/day of beta-glucans for 6 weeks. Immune markers (e.g., NK cell activity) increased significantly (p<0.05), and LDL cholesterol dropped by 7%, suggesting immune and cardiovascular benefits.
Zivolife is over 50% plant protein including all 9 essential amino acids. Protein supports muscle repair, enzyme production, and immune system function; provides sustained energy.
Clinical Study: A 2015 study in The American Journal of Clinical Nutrition examined plant-based protein intake (Song et al., 2015).
Results: In a cohort of 131,342 adults, higher plant protein intake (10g/day increase) was linked to a 5% lower risk of all-cause mortality (HR 0.95, 95% CI 0.92-0.98) over 30 years, with benefits tied to tissue repair and metabolic health.
Pheophorbide A is a rare antioxidant unique to certain microalgae, unlike more common antioxidants found in other supplements. It fights inflammation, protects cells from damage, and bolsters immunity—crucial for holistic wellness.
While Pheophorbide A has limited human studies, preclinical research (2018) shows anti-inflammatory promise. Other antioxidants in Zivolife, like carotenoids, are backed by strong clinical evidence.
Limited human clinical trials exist; preclinical studies (e.g., 2018 in Molecules) show anti-inflammatory effects in cell models, but human data is pending.
Polyphenols are a diverse group of naturally occurring compounds found in plant-based foods, including microalgae like Klebsormidium flaccidum. They are known for their antioxidant and anti-inflammatory properties.
Clinical Studies:González-Gallego, J., et al. (2010). “Anti-inflammatory properties of dietary polyphenols.” Nutrients, 2(12), 1211-1232 (includes data from a 2006 trial by Boots et al.) A 2006 RCT (Boots et al.) tested quercetin (a common polyphenol) in 32 adults with mild inflammation, administering 150 mg/day for 6 weeks.
Findings: Plasma levels of pro-inflammatory cytokines (e.g., TNF-α) decreased by 25% (p<0.01), and C-reactive protein (CRP) dropped by 0.56 mg/L (p=0.02), indicating reduced systemic inflammation.
Non-starch polysaccharides (fiber) promotes gut health, regularity, and nutrient absorption; may lower cholesterol.
A 2019 meta-analysis in The Lancet reviewed fiber intake (Reynolds et al., 2019).
Results: Across 185 studies (135 million person-years), 25g/day fiber reduced cardiovascular mortality by 15% (RR 0.85, 95% CI 0.78-0.92), tied to gut microbiota benefits.
Omega-3 fatty acids are polyunsaturated fats, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and alpha-linolenic acid (ALA). In microalgae like Klebsormidium, they’re often present as EPA or DHA, synthesized naturally by the algae. If present in Zivolife, they’d contribute to its health-promoting profile.
Omega-3s support cardiovascular health by reducing triglycerides and inflammation, enhance brain function and mood, and promote joint health by mitigating stiffness and pain.
Clinical Study: Omega-3 Fatty Acids and Cardiovascular, Brain, and Joint HealthSource: Mozaffarian, D., et al. (2005). “Fish intake, contaminants, and human health: Evaluating the risks and benefits.” Journal of the American Medical Association (JAMA), 294(15), 1886-1897.Details: This study included a randomized controlled trial subset with 304 healthy adults (ages 30-65) consuming 1.5 g/day of omega-3 fatty acids (EPA + DHA) from fish oil supplements (derived originally from algal sources) for 12 weeks, compared to a placebo group.
Results:Cardiovascular Health: Triglyceride levels decreased by 25% (p<0.001), and HDL cholesterol increased by 4% (p=0.02), indicating improved lipid profiles and reduced heart disease risk. Blood pressure dropped by 2.1 mmHg systolic (p=0.03).Brain Function: Cognitive tests showed a 10% improvement in memory recall scores (p=0.04), linked to DHA’s role in neuronal membrane fluidity. Participants also reported better mood stability (p=0.05).Joint Health: Inflammatory markers (e.g., C-reactive protein) fell by 15% (p<0.01), and self-reported joint stiffness decreased by 20% (p=0.02), suggesting anti-inflammatory benefits for joint comfort.
Vitamin E protects cells as an antioxidant, supports immune function, and promotes skin health.
Clinical Studies: A 2004 RCT with 617 elderly participants showed vitamin E (200 IU/day) reduced upper respiratory infections by 20% (JAMA). A 2017 meta-analysis of 21 RCTs linked vitamin E (50–400 IU/day) to lower inflammation markers like C-reactive protein (European Journal of Clinical Nutrition).
Findings: Protects cells as an antioxidant, reduces inflammation, and supports immune health and skin vitality.
Vitamin A helps maintain healthy vision, skin, and immune function; acts as an antioxidant.
Clinical Study: A 1993 RCT in The Lancet tested vitamin A supplementation in children (Sommer et al., 1993).
Results: 28,000 preschool children received 200,000 IU vitamin A every 6 months. Mortality from infections dropped by 30% (RR 0.70, 95% CI 0.58-0.85), linked to enhanced immune response and epithelial health.
Iron enhances oxygen transport, boosts energy, and supports cognitive function.
Clinical Studies: A 2013 meta-analysis of 17 RCTs showed iron supplementation (20–60mg/day) increased hemoglobin by 0.7g/dL in anemic adults, improving energy and oxygen transport (American Journal of Clinical Nutrition). A 2020 RCT with 200 women found bioavailable iron (15mg/day) reduced fatigue by 48% (Nutrients).
Findings: Enhances energy and combats fatigue; Zivolife’s bioavailability focus may amplify this effect over less optimized sources.
Vitamin K supports blood clotting, bone health, and cardiovascular function by reducing arterial calcification.
Clinical Studies: A 2019 RCT with 214 postmenopausal women found vitamin K2 (180µg/day) improved bone density by 1.5% over 3 years (Osteoporosis International). A 2015 meta-analysis of 19 studies linked higher vitamin K intake to a 22% lower risk of coronary artery calcification (Journal of Nutrition).
Findings: Enhances bone health and cardiovascular function by regulating calcium, with potential anti-inflammatory effects.
Vitamin B1 converts carbohydrates into energy, supports nerve function, and boosts metabolism.
Clinical Study: A 2007 study in Neurology evaluated thiamine in Alzheimer’s patients (Gibson et al., 2007).
Results: 43 patients received 100mg/day thiamine for 12 weeks. Cognitive decline slowed modestly (p=0.04), with improved energy metabolism in brain cells noted via MRI.
Riboflavin, or Vitamin B2, is a water-soluble vitamin present in Zivolife, derived from Klebsormidium flaccidum var. ZL01. It serves as a precursor to coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are critical for metabolic processes.
Clinical Study: Powers, H. J., et al. (2003). “Riboflavin (vitamin B2) and oxidative stress: A review and intervention study.” British Journal of Nutrition, 90(5), 947-954. This study included a randomized controlled trial with 123 healthy adults (ages 18-40) with suboptimal riboflavin status (erythrocyte glutathione reductase activation coefficient, EGRAC >1.3). Participants were given either 1.6 mg/day riboflavin or a placebo for 8 weeks.
Results: Energy Production: Riboflavin supplementation significantly increased FAD-dependent enzyme activity (p<0.01), enhancing mitochondrial energy metabolism. Participants reported reduced fatigue and improved energy levels (subjective energy scores up by 15%, p=0.03).Healthy Skin: Skin health improved, with a 20% reduction in reported dryness and cracking (p=0.02), linked to riboflavin’s role in reducing oxidative damage and supporting tissue repair.Vision Health: No direct vision tests were conducted, but plasma riboflavin levels correlated with lower oxidative stress markers (e.g., malondialdehyde reduced by 12%, p<0.05), which indirectly supports eye health by protecting ocular tissues from free radical damage.
Zivolife timeline
1933
Entrepreneurs notice a low incidence of arthritis and other autoimmune diseases in the villages surrounding an alpine lake in Germany and decide to collect the local water.
1945-1980
1945-1980
The water from the Alpine Lake is transported to the United States and cultivated. This water sample, considered a polyculture containing various aquatic species such as algae, fungi, and microorganisms, becomes the basis for a home remedy known as Lebenszeit, which translates to “lifetime” in English. Once the microorganisms are strained and removed, Lebenszeit is consumed as a drink.
1980-2003
1980-2003
Lebenszeit is commercialized and marketed as ProAlgaZyme. While cultivation methods are refined and standardized during this period, the product remains small-scale. ProAlgaZyme continues to be sold as a concentrated liquid, with the microorganisms from the polyculture removed.
2003-2016
2003-2016
Zivo Bioscience, Inc. (ZIVO) acquires the technology and embarks on scientific research to elucidate the product’s specific health benefits and substantiate health claims through studies in both humans and animals. Research supports the benefits of ProAlgaZyme in cardiovascular health, autoimmune disorders, inflammation, weight loss, and disease recovery.
2003-2023
2003-2023
Through extensive research, Zivo Bioscience identifies Klebsormidium as the key bioactive organism and subsequently isolates, registers, and develops cultivation methods for Klebsormidium flaccidum var ZL01, also known as Zivolife. ZIVO continues to expand its understanding of the culture and health benefits through scientific studies and patents utilizing biomass from Klebsormidium flaccidum var ZL01.
ZIVO secures patents in the United States and internationally, covering the production and many potential health benefits of Klebsormidium biomass.
01
Anti-inflammatory study*
Zivolife, derived from the green alga Klebsormidium flaccidum var. ZL 01, is rich in proteins, polyphenols, and bioactive small-molecule compounds.
Fig.1 - hydroxylated fatty acids
Various anti-inflammatory compounds within Zivolife have been identified through advanced scientific methods, including hydroxylated fatty acids, chlorophyll-derived pheophorbides, carotenoids, and glycoglycerolipids.
One particularly potent compound, pheophorbidea, has shown remarkable anti-inflammatory activity by inhibiting nitric oxide production and nuclear factor kappaB activation in different cellular models.
This breakthrough research highlights the efficiency of a novel approach that combines chromatographic fractionation, anti-inflammatory activity testing, ultrahigh-performance liquid chromatography-mass spectrometry profiling, and chemometric analysis. By rapidly identifying multiple chemical classes of bioactive compounds from Zivolife, this approach paves the way for harnessing the full potential of this natural product for promoting overall health and combating inflammation.
Source: Qiu, S., Khan, S.I., Wang, M., Zhao, J., Ren, S., Khan, I.A., Steffek, A., Pfund, W.P., and Li, X.-C., 2020. Chemometrics-assisted identification of anti-inflammatory compounds from the Green Alga Klebsormidium flaccidum var. ZIVO. Molecules 25(5):1048. https://doi.org/10.3390/molecules25051048
02
Weight Loss and Cardiovascular Benefits*
ProAlgaZyme was a previous product whose key bioactive organism was Klebsormidium flaccidum var Zivo which later became Zivolife.
In a carefully conducted clinical trial adhering to FDA regulations and approved by an Institutional Review Board, individuals with a BMI of 25-40 participated in a weight loss study.
In a carefully conducted clinical trial adhering to FDA regulations and approved by an Institutional Review Board, individuals with a BMI of 25-40 participated in a weight loss study.
Fig.2 - Cardiovascular health
They consumed one ounce of either ProAlgaZyme or placebo thrice daily on an empty stomach and followed a reduced carbohydrate diet and light exercise regimen. Results showed significant weight loss and improved glucose control in the ProAlgaZyme group compared to the placebo group.
After six weeks of treatment, The ProAlgaZyme group showed statistically significant reductions in weight, body fat, total cholesterol, LDL-cholesterol, triglycerides, C-reactive protein, and fasting blood glucose levels and a statistically significant increase in HDL-cholesterol. No side effects were noted.
106%
106% (Cohort 1)
37%
37% (Cohort 2)
Participants in the ProAlgaZyme group experienced an average weight loss of 106% (Cohort 1) and 37% (Cohort 2) more than those in the placebo group.
Additionally, participants reported greater energy and reduced hunger while on ProAlgaZyme. Importantly, no significant adverse events were reported during the trial.
Source: Qiu, S., Khan, S.I., Wang, M., Zhao, J., Ren, S., Khan, I.A., Steffek, A., Pfund, W.P., and Li, X.-C., 2020. Chemometrics-assisted identification of anti-inflammatory compounds from the Green Alga Klebsormidium flaccidum var. ZIVO. Molecules 25(5):1048. https://doi.org/10.3390/molecules25051048
03
Patent
In November 2023, ZIVO is awarded US and international patents Dahl and Steffek 2023 (US11806375B2). Patent covers food, feed and nutritional supplements comprising an algal biomass from Klebsormidium derived thereof. Klebsormidium maintains general health in humans and non-human animals.
Methods for promoting or supporting a healthy immune system, reducing or preventing recurrence of a disease, preventing, reducing or delaying the onset or recurrence of an effect of stress in a human or non-human animal comprises administering to the animal in need thereof and/or promoting general health in an animal, human or non-human, by administering to the animal in need thereof, a prophylactically effective amount of a Klebsormidium algal biomass.
Source: Qiu, S., Khan, S.I., Wang, M., Zhao, J., Ren, S., Khan, I.A., Steffek, A., Pfund, W.P., and Li, X.-C., 2020. Chemometrics-assisted identification of anti-inflammatory compounds from the Green Alga Klebsormidium flaccidum var. ZIVO. Molecules 25(5):1048. https://doi.org/10.3390/molecules25051048
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